Gwern modafinil

Remember me This is not recommended for shared computers. Sign in anonymously Don't add me to the active users list. Posted 27 September - PM. Hey guys, I was wondering if you know of any sources inside the USA that ship modafinil. I would rather not order international, since I don't want to risk my college receiving a customs letter. Any help would be much appreciated.

Posted 28 September - PM. To answer your question though, nubrain. Posted 29 September - AM. Posted 29 September - PM. Posted 30 September - AM. Posted 02 October - AM. There is a European supplier that has it in bulk with coa's and metal testing.

Posted 04 October - PM. Posted 05 October - AM. Posted 12 October - PM. Posted 13 October - PM. Posted 14 October - AM.

Posted 14 October - PM. Anyone have experiences with this?

Modafinil Sources

I actually have a script for this, but insurance won't brands no generic form in US. Posted 11 November - AM. A user over at Reddit made this; I assume it will of some use to people around here. Posted 11 November - PM. Posted 12 November - PM. Are you reading that chart correctly? The way I read it, airsealed is about 2x the cost of the ones at the top of the list. The cost in the last column is the amount of modafinil per each dollar, isn't it? Posted 17 November - PM. Posted 11 January - PM.

Posted 16 January - PM. Posted 21 February - AM. Posted 22 February - AM. Posted 22 February - PM. This is from a spreadsheet I developed after doing extensive research on various forums.

See link The two I've highlighted are best in terms of the quality of the product produced under the brand, reliability of the internet pharmacy and overall price.

gwern modafinil

Posted 23 February - AM. It's ordered by absolute price:. Posted 23 February - PM. Community Forum Software by IP.Notes on nootropics I tried, and my experiments nootropicspsychologyexperimentspredictionsstatisticsDNBshellHaskellRpower-analysissurveyBayesreviews — in progress certainty : likely importance : 7. A record of Nootropics are drugs, supplements, and other substances that may improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.

gwern modafinil

While many substances are purported to improve cognition, research is at a preliminary stage as ofand the effects of the majority of these agents are not fully determined. Your mileage will vary. There are so many parameters and interactions in the brain that any of them could be Liebig law of the minimumoften simply called Liebig's law or the law of the minimumis a principle developed in agricultural science by Carl Sprengel and later popularized by Justus von Liebig.

8 Thoughts On Modafinil - Pros \u0026 Cons Of Modafinil / Provigil -

It states that growth is dictated not by total resources available, but by the scarcest resource. The law has also been applied to biological populations and ecosystem models for factors such as sunlight or mineral nutrients.

The dose—response relationshipor exposure—response relationshipdescribes the magnitude of the response of an organism, as a function of exposure to a stimulus or stressor after a certain exposure time. Dose—response relationships can be described by dose—response curves.

This is explained further in the following sections. A stimulus response function or stimulus response curve is defined more broadly as the response from any type of stimulus, not limited to chemicals. The Yerkes—Dodson law is an empirical relationship between pressure and performance, originally developed by psychologists Robert M. Yerkes and John Dillingham Dodson in The law dictates that performance increases with physiological or mental arousal, but only up to a point.

When levels of arousal become too high, performance decreases. The process is often illustrated graphically as a bell-shaped curve which increases and then decreases with higher levels of arousal. The original paper was only referenced ten times over the next half century, yet in four of the citing articles, these findings were described as a psychological "law.

A failure to adapt to novel or changing environmental demands is a core feature of a wide variety of neuropsychiatric disorders as well as the normal states of stress and fatigue. We review the neurochemistry of cognitive control, which has been associated primarily with the prefrontal cortex. Many drugs affect the functioning of the prefrontal cortex, but the direction and extent of drug effects vary across individuals and tasks. Apparently paradoxical effects are often observed, where the same medication causes both cognitive enhancement as well as cognitive side effects.

We review neurobiological research that is beginning to elucidate the nature of these contrasting effects and the factors underlying the large variability across individuals and behaviours. It has been suggested that the recent rapid developments in the fields of neuroscience and psychopharmacology have increased the possibilities for pharmacological enhancement of mental functioning.It's worth noting that not everyone responds to modafinil.

If you've had genetic sequencing done I had mine done by 23andmeyou can predict your response by checking your Rs status. I'm A;A, and normally have almost no response to modafinil. I discovered, however, that I have significant modafinil response while on an MAOI transdermal selegiline.

I've stopped taking it recently, since I've finally tracked down the primary causes of my excessive sleepiness, very deficient in vitamin D and cortisol.

Modafinil has been a massive help both with fatigue and depression, and let me stay functional and productive through a difficult time in my life while I tracked down the actual problems.

Contrary to what some doctors tell you, it is really hard to fix a Vitamin D deficiency with dietary supplements. Go to a tanning salon and get ,IUs in 10 minutes. Of course this is going to be a bit weird if you are naturally dark skinned, but far more effective than taking pills. I ask because I'm interested in making sure I'm healthy, not to just be a jerk on the internet, and if that's true I'm doing something wrong.

No citations exist. My comment was directed at the grandparent whose original symptoms warranted taking dangerous MAOIs. In that case, I would consider an off literature treatment to fix the vitamin D deficiency as fast as possible. Tanning beds are carcinogenic and not recommended for general health. I started taking MAOIs while trying to deal with depression. You're right about dangerous, though.

I first started modafinil while on the MAOI, and didn't find out that it didn't work for me off of it until I stopped using the MAOI due to apparent serotonin toxicity, which you don't want to screw around with.

Oral vitamin D is not taken up by the body all that well. If you do have a D deficiency and you're taking oral supplements, be sure to get your levels checked after 6 months. You may need to up your dose or get some direct sunlight. For me at least, this is certainly true.

I hadn't considered visiting a tanning salon; I may try that soon if things aren't notably improved after the next time I get this tested. I'm A;G - anyone know what that might mean? Any idea why that genotype wasn't in the study? TheSOB88 on Feb 27, Deficient in cortisol? That sounds very interesting Isn't that the stress hormone?Adrafinil is one of several nootropic drugs that have not yet been regulated by the FDA. Although it is said to be about three times less effective than the FDA-approved, prescription-only modafinil, adrafinil a modafinil precursor can be a better choice for a mild cognitive enhancer as it is legal to buy over the counter.

Although the original Olmifon brand is no longer available in stores, you can still get quality generic adrafinil from many nootropics vendors. The following are a couple trustworthy online stores where you can order pure, lab-tested adrafinil capsules or powder. This US-based vendor sells high quality nootropics and medicinal mushrooms. Their products are tested for purity in US labs and you can view the certificates on their website.

Pure Nootropics have very helpful and committed customer service. Their products come in different quantities and forms including pure powder, vegetarian capsules, and gelatin softgels. Products They Sell: Adrafinil, noopept, aniracetam, phenylpiracetam, choline, and many other natural supplements and chemical cognitive enhancers. Go to Pure Nootropics.

Health Naturals has been selling quality dietary supplements for well over a decade. They have recently introduced many nootropics to their online shop and they are one of the top rising vendors in this category.

Most of the nootropics sold at Health Naturals come in capsules, and include a recent Certificate of Analysis showing lab test results. Go to Health Naturals. They are not very popular these days, but still offer some quality brands of supplements. The AntiAging Store sell a branded generic version of adrafinil called Adra-Pro, which comes in mg tablets. They also sell other branded nootropics, including aniracetam, piracetam, picamilon, and even modafinil — cough cough!

Go to AntiAging Store.

Nootropics

There used to be several adrafinil products on Amazon from different sellers, but Amazon have lately wiped out all adrafinil supplements from their websites in the US, UK, EU and other countries. They have also removed most other nootropic drugs, particularly racetams and their analogues. I could only find a few adrafinil listings on the Amazon Canada website, which only ships to Canada. They will probably take those down soon too.

Although Amazon is one of the top popular places to buy supplements from, adrafinil is not a dietary or nutritional supplement, but rather a synthetic chemical drug. Amazon, like many other major retailers and nutrition stores, have opted not to deal with unapproved drugs that may pose a considerable legal liability risk, and many nootropic drugs are just that, despite being legal!

It is not likely that Amazon will change their mind and bring adrafinil and other nootropics back to their websites, especially that the legal noose is becoming tighter around many unscheduled drugs in the US and other countries around the world. Again, the reason is that adrafinil is not a dietary supplement neither an approved drug. Most consumers buy adrafinil from online suppliers since it is extremely unlikely to be found in local stores whether in the USA or elsewhere.

gwern modafinil

Adrafinil belongs to a class of drugs known as eugeroics or eugregorics, aka wakefulness-promoting agents or drugs. It was originally used to improve wakefulness, arousal and alertness in elderly patients who suffer from sleep disorders, including narcolepsy and excessive daytime sleepiness. It is also widely used off-label as a nootropic or cognitive enhancer. This drug was first discovered and synthesized in France by Louis Lafon Laboratories.

It has various chemical names synonyms including: 2- Benzhydrylsulfinyl acetohydroxamic acid, 2-benzhydrylsulfinylethanehydroxamic acid, 2- Diphenylmethyl sulfinyl acetohydroxamic acid, and others.

Adrafinil is a precursor for modafinil.Modafinil is a prescription stimulant drug. Modafinilsold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea.

While it has seen off-label use as a purported cognitive enhancer, the research on its effectiveness for this use is not conclusive. It is taken by mouth. Its development stems from Adrafinil is a eugeroic that was formerly used in France to promote alertness, attention, wakefulness, positive mood, and other parameters, particularly in the elderly.

It was also used off-label by individuals who wished to avoid fatigue, such as night workers or others who needed to stay awake and alert for long periods of time. Additionally, "adrafinil is known to a larger nonscientific audience, where it is considered to be a nootropic agent. So you can either try to convince a doctor to give you a prescription or deal with dubious online pharmacies or suppliers in countries where modafinil is available over-the-counter.

The former way is annoying and you pay full price, and the latter way is unreliable and still expensive—you may be buying at a lower price, but the risks of seizure at the border, shipping, possibly paying for laboratory assays etc.

The presence of food in the gastrointestinal tract can slow the rate but does not affect the total extent of absorption.

Steady-state plasma concentrations are achieved between 2 and 4 days with repeated dosing. The major circulating metabolites modafinil acid and modafinil sulfone do not appear to exert any significant activity in the brain or periphery Robertson and Hellriegel, The elimination half-life is approximately h Wong et al, aand single daily dosing is adequate and common in clinical practice.

Modafinil has a couple different but closely related benefits. It is overall a better stimulant than caffeine or the amphetamines 11and targets different receptors than the amphetamines. It emphasizes caution, pausing and review before leaping into new innovations that may prove disastrous.

Critics argue that it is vague, self-cancelling, unscientific and an obstacle to progress. In addition, modafinil at well-tolerated doses improves function in several cognitive domains, including working memory and episodic memory, and other processes dependent on In mammalian brain anatomy, the prefrontal cortex PFC is the cerebral cortex which covers the front part of the frontal lobe.

Mood was assessed daily using both the Positive and Negative Affect Schedule and a general mood scale, which consisted of 10 bipolar adjective ratings based on a severity scale ranging from 1 to Modafinil increased general mood and Negative Affect scales relative to placebo and had a significant effect on Positive Affect scales.

These results suggest that modafinil may have general mood-elevating effects accompanied by increased negative affect anxiety. The findings may have implications for clinical practice, in particular for the adjunctive use of modafinil in treatment-resistant depression Goss et almeta-analyzing the depression trials, finds.

The treatment effects were evident in both MDD and bipolar depression, with no difference between disorders.Citations for biomedical literature. Reliable, up-to-date health information for you. An experimental multimedia search engine. Medical Subject Headings. A database of clinical studies, worldwide. Basic Local Alignment Search Tool. Director's Blog.

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Investigate training opportunities. About NLM. Explore our past. Explore the Library.Medically reviewed by Drugs. Last updated on Jun 8, Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take modafinil with all of your drugs and health problems.

Do not start, stop, or change the dose of any drug without checking with your doctor. Use modafinil as ordered by your doctor.

Read all information given to you. Follow all instructions closely. Modafinil dosage information in more detail. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at Modafinil side effects in more detail.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Other brands: Provigil.

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Skip to Content. See also: Modafinil dosage information in more detail. See also: Modafinil side effects in more detail. Drug Status Availability Prescription only Rx.


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